SrasV1, France, Analysis, bibRecord, 000314

Design and Synthesis of Hydroxyferroquine Derivatives with Antimalarial and Antiviral Activities

Identifieur interne : 000314 ( France/Analysis ); précédent : 000313; suivant : 000315

Design and Synthesis of Hydroxyferroquine Derivatives with Antimalarial and Antiviral Activities

Auteurs : Christophe Biot [Belgique, France] ; Wassim Daher [Belgique] ; Natascha Chavain [Belgique] ; Thierry Fandeur [Belgique] ; Jamal Khalife [Belgique] ; Daniel Dive [Belgique] ; Erik De Clercq [Belgique]

Source :

Journal of Medicinal Chemistry [ 0022-2623 ] ; 2006.

RBID : ISTEX:30822F0447A99B08EE0DB930AA9DE4D69582FE66

Descripteurs français

English descriptors

KwdEn :
- Aminoalcohol, Animals, Antimalarial, Antimalarials (chemical synthesis), Antimalarials (chemistry), Antimalarials (pharmacology), Antimalarials (toxicity), Antiprotozoal agent, Antiviral, Antiviral Agents (chemical synthesis), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Antiviral Agents (toxicity), Biological activity, Chemical synthesis, Coronavirus, Drug Design, Ferrous Compounds (chemical synthesis), Ferrous Compounds (chemistry), Ferrous Compounds (pharmacology), Ferrous Compounds (toxicity), HIV-1 (drug effects), In vitro, Metallocene, Molecular Structure, Parasiticide, Plasmodium falciparum, Plasmodium falciparum (drug effects), Primary alcohol, Quinoline derivatives, Quinolines (chemical synthesis), Quinolines (chemistry), Quinolines (pharmacology), Quinolines (toxicity), SARS Virus (drug effects).
MESH :
- chemical , chemical synthesis : Antimalarials, Antiviral Agents, Ferrous Compounds, Quinolines.
- chemical , chemistry : Antimalarials, Antiviral Agents, Ferrous Compounds, Quinolines.
- chemical , pharmacology : Antimalarials, Antiviral Agents, Ferrous Compounds, Quinolines.
- chemical , toxicity : Antimalarials, Antiviral Agents, Ferrous Compounds, Quinolines.
- drug effects : HIV-1, Plasmodium falciparum, SARS Virus.
- Animals, Drug Design, Molecular Structure.

Abstract

Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS−CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.

Url:

DOI: 10.1021/jm0601856

Affiliations:

Belgique, France

Links to Exploration step

ISTEX:30822F0447A99B08EE0DB930AA9DE4D69582FE66

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aminoalcohol</term>
<term>Animals</term>
<term>Antimalarial</term>
<term>Antimalarials (chemical synthesis)</term>
<term>Antimalarials (chemistry)</term>
<term>Antimalarials (pharmacology)</term>
<term>Antimalarials (toxicity)</term>
<term>Antiprotozoal agent</term>
<term>Antiviral</term>
<term>Antiviral Agents (chemical synthesis)</term>
<term>Antiviral Agents (chemistry)</term>
<term>Antiviral Agents (pharmacology)</term>
<term>Antiviral Agents (toxicity)</term>
<term>Biological activity</term>
<term>Chemical synthesis</term>
<term>Coronavirus</term>
<term>Drug Design</term>
<term>Ferrous Compounds (chemical synthesis)</term>
<term>Ferrous Compounds (chemistry)</term>
<term>Ferrous Compounds (pharmacology)</term>
<term>Ferrous Compounds (toxicity)</term>
<term>HIV-1 (drug effects)</term>
<term>In vitro</term>
<term>Metallocene</term>
<term>Molecular Structure</term>
<term>Parasiticide</term>
<term>Plasmodium falciparum</term>
<term>Plasmodium falciparum (drug effects)</term>
<term>Primary alcohol</term>
<term>Quinoline derivatives</term>
<term>Quinolines (chemical synthesis)</term>
<term>Quinolines (chemistry)</term>
<term>Quinolines (pharmacology)</term>
<term>Quinolines (toxicity)</term>
<term>SARS Virus (drug effects)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Antipaludiques ()</term>
<term>Antipaludiques (pharmacologie)</term>
<term>Antipaludiques (synthèse chimique)</term>
<term>Antipaludiques (toxicité)</term>
<term>Antiviraux ()</term>
<term>Antiviraux (pharmacologie)</term>
<term>Antiviraux (synthèse chimique)</term>
<term>Antiviraux (toxicité)</term>
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<term>Composés du fer II (pharmacologie)</term>
<term>Composés du fer II (synthèse chimique)</term>
<term>Composés du fer II (toxicité)</term>
<term>Conception de médicament</term>
<term>Plasmodium falciparum ()</term>
<term>Quinoléines ()</term>
<term>Quinoléines (pharmacologie)</term>
<term>Quinoléines (synthèse chimique)</term>
<term>Quinoléines (toxicité)</term>
<term>Structure moléculaire</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) ()</term>
<term>Virus du SRAS ()</term>
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<term>Antiviral Agents</term>
<term>Ferrous Compounds</term>
<term>Quinolines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antimalarials</term>
<term>Antiviral Agents</term>
<term>Ferrous Compounds</term>
<term>Quinolines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antimalarials</term>
<term>Antiviral Agents</term>
<term>Ferrous Compounds</term>
<term>Quinolines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Antimalarials</term>
<term>Antiviral Agents</term>
<term>Ferrous Compounds</term>
<term>Quinolines</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>HIV-1</term>
<term>Plasmodium falciparum</term>
<term>SARS Virus</term>
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<term>Antiviraux</term>
<term>Composés du fer II</term>
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<keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Antipaludiques</term>
<term>Antiviraux</term>
<term>Composés du fer II</term>
<term>Quinoléines</term>
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<keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Antipaludiques</term>
<term>Antiviraux</term>
<term>Composés du fer II</term>
<term>Quinoléines</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Drug Design</term>
<term>Molecular Structure</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Antipaludiques</term>
<term>Antiviraux</term>
<term>Composés du fer II</term>
<term>Conception de médicament</term>
<term>Plasmodium falciparum</term>
<term>Quinoléines</term>
<term>Structure moléculaire</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Activité biologique</term>
<term>Alcool primaire</term>
<term>Aminoalcool</term>
<term>Antipaludique</term>
<term>Antiparasitaire</term>
<term>Antiprotozoaire</term>
<term>Antiviral</term>
<term>Coronavirus</term>
<term>Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl])</term>
<term>Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]-N-méthyl)</term>
<term>Ethanolamine(N-[(2-[([7-chloro-4-quinolyl]amino)méthyl]ferrocényl)méthyl]-N-éthyl)</term>
<term>Ferrocène dérivé</term>
<term>In vitro</term>
<term>Métallocène</term>
<term>Plasmodium falciparum</term>
<term>Quinoléine dérivé</term>
<term>Synthèse chimique</term>
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<front><div type="abstract">Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS−CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.</div>
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Design and Synthesis of Hydroxyferroquine Derivatives with Antimalarial and Antiviral Activities

Design and Synthesis of Hydroxyferroquine Derivatives with Antimalarial and Antiviral Activities

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